Claudio Ortenzi

Claudio Ortenzi

Professore di ruolo - I fascia / Zoologia (BIO/05)
Prorettore Vicario, delegato del Rettore per la didattica
  • Tel. interno (+39) 0733 258 5820
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Dipartimento di Scienze della Formazione, dei Beni Culturali e del Turismo

Nome:                Claudio Ortenzi

Data e luogo

di nascita:          19 gennaio 1958, Macerata

Indirizzo:           Università di Macerata

Dipartimento di Scienze della formazione, dei Beni culturali e del Turismo

62100 Macerata

Tel.:                   0733.2585820


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Altri corsi e risorse su piattaforme esterne

  • BIO/05 - Zoologia
Informazione non pervenuta
Lingua Conoscenza
Inglese Buono
Aree: Asia, Europa, Italia
Paesi: Italia
Titolo Geni e molecole dell’immunità degli invertebrati. Struttura, funzioni, precursori evolutivi e trasferibilità nella ricerca applicata
Settore ERC LS2: Genetics, Genomics, Bioinformatics and Systems Biology: genetics, population genetics, molecular genetics, genomics, transcriptomics, proteomics, metabolomics, bioinformatics, computational biology, biostatistics, biological modelling and simulation, systems biology, genetic epidemiology
Abstract microorganisms mainly resides in their ability to use different types of molecules, either specifically synthesized or secondarily derived from a variety of metabolic
pathways, to govern most of the basic vital functions such as chemical communication, self/nonself recognition, interactions with the environment and prey/predator,
defense against pathogens, control of demographic expansion (vegetative growth), and sexual phenomena. Among these microorganisms, ciliates in particular
represent excellent material to study biomolecules, as clearly specified in various protozoological textbooks since the half of past century, and testified by the Nobel
Prizes in Medicine conferred to Tom Cech (1989), Elisabeth Blackburn (2009) and Carol Greider (2009), who all developed their researches on the ciliates
Tetrahymena and Euplotes. There are practical and scientific reasons that strongly support this concept. Major practical reasons are the following: (i) ciliates are very
rich in species -- nearly 10,000 are known uniquely on morphological grounds -- ubiquitously distributed and easily isolable from every aquatic habitat as well as from
the soil; (ii) their wild representatives (isolates) can promptly be adapted to multiply (virtually indefinitely) into massive laboratory cultures which can be expanded (at
very reduced costs) to virtually unlimited dimensions; (iii) they are unique for a genetic organization that greatly facilitates gene identification and cloning, their
expressed genome (contained in the somatic nucleus, or macronucleus) being formed not by chromosomic genes, but by individual (sub-chromosomic)
transcriptionally active gene-sized DNA molecules each one replicated to thousands of copies. With regard to the scientific reasons it may be here sufficient to recall
that ciliates are credited to be holders of most of the fundamental eukaryotic “inventions” because (together with the Dinozoa and Apicomplexa which are their close
phylogenetic relatives) they form one of the most successful clade (the Alveolata) of eukaryotic organisms evolved at the roots of the explosion of the eukaryotic life.
Therefore, we can be confident that the conclusions drawn from the experimental analysis of these inventions -- which, furthermore, are the result of strong selective
pressure because they coexist imbedded in a unique biological matrix directly exposed to the environment -- are fully applicable to organisms that are more complex
and difficult to examine.
This RU is directed to study signaling proteins (pheromones) and secondary metabolites of ciliates: pheromones will be studied in function of their activity in
self/nonself recognition mechanisms and the secondary metabolites in function of their cytotoxic activities which have interesting perspectives in medical and
pharmacological applied research. Relevant research aspects of this RU involve a close collaboration with the RU's of the Universities of La Tuscia and Trento with
which this collaboration dates back to a previous PRIN project (2008) and is demonstrated by publications edited in peer-reviewed journals. In the laboratories of
these three RU's there is full availability of the necessary technological and instrumental resources, as well as of the necessary research material which is represented
by a vast collection of marine and freshwater ciliate species, that are the result of many years of sampling and isolation from many different geographic areas
(including the freezing waters of the Poles).
Parole chiave secondary metabolites, cytotoxicity, anticancer metabolites
Gruppo di lavoro Claudio Ortenzi, Federico Buonanno, Graziano Guella, Claudio Alimenti, Adriana Vallesi
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